AST Sports Science | Breaking Research 3-11-99

Creatine increases muscle strength in patients with neuromuscular disease.

A recent Canadian research study published in the March 10th issue of Neurology revealed a group of patients with muscular dystrophy and other neuromuscular disorders showed vast improvements in muscle strength and lean body mass when treated with creatine monohydrate.

Dr. Mark Tarnopolsky and Joan Martin, of McMaster University Medical Center in Hamilton, Ontario, Canada, treated 81 patients with 10 g of creatine monohydrate daily for 5 days followed by 5 g daily for 5 to 7 days in an open-label study. In a second, single-blind study they treated 21 patients with creatine monohydrate.

The researchers measured handgrip, dorsiflexion, knee extensor strength and body weight before and after treatment.

"Creatine administration increased all measured indices in both studies," Dr. Tarnopolsky and Martin report.

"Our data represented the entire group of patients...because we did not find any subgroup differences in the response for each of the classified groups," the Canadian researchers note.

Neurology 1999;52:854-857.


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